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| <td align=center><font color='blue' size='+2'>The Architecture of Robust, Evolvable Networks</font></td> | <td align=center><font color='blue' size='+2'>The Architecture of Robust, Evolvable Networks</font></td> | ||
| < | <td rowspan=2 align=center> </td></tr> | ||
| < | <tr valign=top><td align=center><font color='blue' size='+1'>Winter 2010</font></td></tr> | ||
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| <td align=center><font color='blue' size='+1'>Winter 2010</font></td> | |||
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| </table> | </table> | ||
| <table align=right><tr><td>__TOC__</td></tr></table> | |||
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| * Instructor: [http://www.cds.caltech.edu/~doyle2/wiki/index.php?title=J._Doyle’s_Bio John C. Doyle] | * Instructor: [http://www.cds.caltech.edu/~doyle2/wiki/index.php?title=J._Doyle’s_Bio John C. Doyle] | ||
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| * [http://listserv.cds.caltech.edu/mailman/listinfo/cds-213 Course mailing list] | * [http://listserv.cds.caltech.edu/mailman/listinfo/cds-213 Course mailing list] | ||
| * Lectures: TTh 4-5:30 pm,  | * Lectures: TTh 4-5:30 pm, 107 Annenberg, changes emailed to course mailing list | ||
| </td> | </td></tr></table> | ||
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| </table> | |||
| == Course Schedule == | == Course Schedule == | ||
| {| border=1 width=100% | {| border=1 width=100% | ||
| |- | |- | ||
| | Week || Date || Topic || Reading | | Week || Date || Topic || Reading | ||
| |- | |- | ||
| | align=center rowspan= | | align=center rowspan=3 | 1   | ||
| | colspan=3 | '''Introduction to  | | colspan=3 | '''Introduction to Network Architectures''' | ||
| |- | |- | ||
| |  | | 12 Jan (T) | ||
| | [[IST Seminar: The Architecture of Robust, Evolvable Networks]] | | [[IST Seminar: The Architecture of Robust, Evolvable Networks]] | ||
| |   | |   | ||
| |- | |- | ||
| |  | | 14 Jan (Th) | ||
| | [[ | | [[Internet Architecture]] | ||
| | [ | | Network is IPC:[[Media:IPC-arch-rearch08.pdf | Day et al, 2008 (Paper)]];[[Media:IPC-arch.pdf | Matta (Slides)]]; [[Media:DAYIEEECCW2009.pdf | Implications PNA, Day, 2009 (Slides)]];[[Media:Touchccw2009.pdf | Multihop/Multiparty influences on Net. Arch., Touch (Slides)]] | ||
| |  | |||
| |- | |- | ||
| | align=center rowspan=3 | 2 | | align=center rowspan=3 | 2 | ||
| |  | | colspan=3 | '''Network Architectures: Operating Systems and Cell Biology ''' | ||
| |  | |||
| |- | |- | ||
| | 19 Jan (T) | | 19 Jan (T) | ||
| | [[ | | [[Network Architectures: Internet vs. Biology| Internet and Biology Architectures]] | ||
| | [[Media:RINA_Security_11209.pdf | <i>Assessing Security of a Clean Slate Internet Architecture </i>, Boddapati, Day]];[[Media:GlycolysisACCFinal.pdf | <i>Linear Control Analysis of the Autocatalytic Glycolysis System </i>, Chandra, Buzi, Doyle]] | |||
| |- | |- | ||
| | 21 Jan (Th) | | 21 Jan (Th) | ||
| |  | | [[Robustness and Fragility, Hard limits and Tradeoffs| Robustness and Fragility, Hard Limits and Tradeoffs]] | ||
| |   | | [[Media:TAC-statmech-revised-final.pdf | <i>On Lossless Approximations, Fluctuation-Dissipation and Limitations of Measurements </i>, Sandberg, Doyle]] | ||
| |- | |- | ||
| | align=center rowspan= | | align=center rowspan=3 | 3 | ||
| | colspan=3 | ''' | | colspan=3 | '''Case Studies: Cell Biology, Clothing and Legos ''' | ||
| |- | |- | ||
| | 26 Jan (T) | | 26 Jan (T) | ||
| | [[ | | [[Glycolysis | Network architecture and control of glycolysis; Clothing; Legos]] | ||
| |  | | [[Media:GlycolysisACCFinal.pdf | <i>Linear Control Analysis of the Autocatalytic Glycolysis System </i>, Chandra, Buzi, Doyle]];[[Media:RedBloodCellsGlycolysis.pdf | <i>Assembly and Regulation of a Glycolytic Enzyme Complex on the Human Erythrocyte Membrane </i>, Campanella et al]] | ||
| |- | |- | ||
| | 28 Jan (Th) | | 28 Jan (Th) | ||
| | [[ | | [[ Heat Shock| Heat Shock in cells; Clothing; Legos]] | ||
| |  | |[[Media: PNASHeatShock.pdf | <i>Surviving Heat Shock: Control strategies for robustness and performance </i>, El-Samad, et al]];[[Media: Cell.pdf |<i> Robustness of Cellular Functions Review</i>, Stelling, et al]];[[Media: ScienceOnlinePDF.pdf | <i>Reverse Engineering of Biological Complexity</i>, Csete, Doyle]] | ||
| |- | |||
| | align=center rowspan=3 | 4 | |||
| | colspan=3 | '''Naming, Addressing and Control in Cell Biology ''' | |||
| |- | |- | ||
| | 2 Feb (T) | | 2 Feb (T) | ||
| | [[ | | [[Naming, Addressing and Control in Cell Biology | Naming, Addressing and Control in Cell Biology ]] | ||
| |  | | [http://www.cds.caltech.edu/~doyle/213/Feb02SlidesReading/Final_IEE_SB.pdf <i>Highly optimised global organisation of metabolic networks</i>, R. Tanaka, M. Csete and J. Doyle];[http://www.cds.caltech.edu/~doyle/213/Feb02SlidesReading/ScaleRichMetabolism.pdf <i>Quantitative evaluation of scale-rich metabolic networks, Tanaka, Doyle] | ||
| |- | |- | ||
| | 4 Feb (Th) | | 4 Feb (Th) | ||
| | [[ | | [[ Signal Transduction | Signal Transduction]] | ||
| |  | |[http://www.cds.caltech.edu/~doyle/213/Feb02SlidesReading/YiEtAlPNAS.pdf Robust perfect adaptation in bacterial chemotaxis through integral feedback control, Yi, Huang, Simon and Doyle]; [http://www.amazon.com/Introduction-Systems-Biology-Mathematical-Computational/dp/1584886420  Chapter 7: Robustness of Protein Circuits: The Example of Bacterial Chemotaxis of "An Introduction to Systems Biology", Uri Alon] | ||
| |- | |- | ||
| |  | | align=center rowspan=3 | 5 | ||
| | [[ | | colspan=3 | '''Architecture and Modeling in Cell Biology ''' | ||
| |  | |- | ||
| | 9 Feb (T) | |||
| | [[Modeling Biological Systems | Architecture and Layering in Cell Biology]] | |||
| |   | |||
| |- | |- | ||
| | 11 Feb (Th) | | 11 Feb (Th) | ||
| | [[ | | [[ Modeling Biological Systems | Modeling Bio Systems, Speaker: James Faeder]] | ||
| |[http://www.cds.caltech.edu/~doyle/213/Feb09weekSlidesReading/Faeder_2009.pdf Rule-Based Modeling of Biochemical Systems with BioNetGen, Faeder, Blinov and Hlavacek]; [http://www.cds.caltech.edu/~doyle/213/Feb09weekSlidesReading/Bioinformatics09a_inpress.pdf Simulation of large-scale rule-based models, Colvin et al.]; [http://www.cds.caltech.edu/~doyle/213/Feb09weekSlidesReading/FaederPerspectives.pdf The Complexity of Cell Signaling and the Need for a New Mechanics, Hlavacek and Faeder];[http://www.cds.caltech.edu/~doyle/213/Feb09weekSlidesReading/STKE2006.pdf Rules for Modeling Signal-Transduction Systems, Hlavacek et al.]; [http://www.cds.caltech.edu/~doyle/213/Feb09weekSlidesReading/nri-published.pdf Mathematical and Computational Models of Immune-Receptor Signalling, Goldstein et al.] | |||
| |- | |- | ||
| | align=center rowspan= | | align=center rowspan=3 | 6 | ||
| | colspan=3 | ''' | | colspan=3 | '''Complexity and Fragility ''' | ||
| |- | |- | ||
| |  | | 16 Feb (T) | ||
| | [[ | | [[Complexity and Fragility | Complexity and Fragility: Examples with NPP and Mandelbrot sets]] | ||
| |  | | [http://www.cds.caltech.edu/~doyle/213/Feb16weekSlidesReading/logFinalCDC2006_X.pdf  Complexity in Automation of SOS Proofs: An Illustrative Example, Gayme et al.];[http://www.cds.caltech.edu/~doyle/213/Feb16weekSlidesReading/mandel2.pdf <i>Optimization Based Methods for Determining Basins of Attraction in the Logistic Map and Set Membership in the Mandelbrot Set</i>, Gayme et al. ]; [http://www.cds.caltech.edu/~doyle/213/Feb16weekSlidesReading/DenniceConnections2006.pdf Studying the Logistic Map and the Mandelbrot Set Using SOS Methods, Gayme, Fazel, Doyle] | ||
| |- | |- | ||
| | 18 Feb (Th) | | 18 Feb (Th) | ||
| | [[ | | [[Complexity and Fragility | Complexity and Fragility (continued)]] | ||
| | [http://www.cds.caltech.edu/~doyle/213/Feb16weekSlidesReading/AldersonDoyle-SMCA.pdf Contrasting Views of Complexity and Their Implications For Network-Centric Infrastructures, Alderson, Doyle ] | |||
| | [ | |||
| |- | |- | ||
| |  | | align=center rowspan=3 | 7 | ||
| |  | | colspan=3 | '''Power Laws/ TCP IP ''' | ||
| |  | |||
| |- | |- | ||
| |  | | 23 Feb (T) | ||
| | [[ | | [[Power Laws | Power Laws]] | ||
| |  | | [http://www.cds.caltech.edu/~doyle2/wiki/index.php?title=Power_Laws Reading ] | ||
| |- | |- | ||
| |  | | 25 Feb (Th) | ||
| | [[The Internet | Steven Low guest speaker: TCP IP]] | |||
| | [http://www.cds.caltech.edu/~doyle2/wiki/index.php?title=The_Internet Reading ] | |||
| | [[ | |||
| |  | |||
| |- | |- | ||
| |- | |- | ||
| |} | |} | ||
| == Course  | == Course Projects == | ||
| There will be a course project to be discussed. | |||
| [[ | * [[Molecular Cell Biology Project | Molecular Cell Biology Project]] | ||
Latest revision as of 17:36, 3 April 2010
| The Architecture of Robust, Evolvable Networks | ||
| Winter 2010 |